SKU: AH_GH_AR_2762 Category:

Generic : Esomeprazole (20mg)

Treatment : Gastroesophageal reflux , Peptic ulcer ,

Pack size  : 15 (Tablet)

Manufacturer : Pfizer Ltd

Made In : INDIA



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Neksium 20 Tablet is used to treat conditions related to excessive stomach acid production, such as gastroesophageal reflux disease (GERD), peptic ulcer disease, and Zollinger-Ellison syndrome. It reduces the amount of acid produced in the stomach and provides relief from symptoms and promotes healing.

Neksium 20 Tablet can also be used to prevent stomach ulcers caused by certain medications, such as nonsteroidal anti-inflammatory drugs (NSAIDs). Take the medicine as per your doctor’s prescription. The dose will depend on what you are being treated for, but it is usually the lowest dose for the shortest time that is needed to treat your condition. It is usually taken on an empty stomach, preferably in the morning or at least 1 hour prior to meal. Continue taking the medicine even if your symptoms disappear until the doctor say it is okay to stop. If you are taking this medicine for a long time, your doctor may carry out regular tests to check your levels of magnesium which can fall with this medicine.

This medicine is not suitable for some people. Before taking this medicine, you need to tell your doctor if you have severe liver problems, are taking medicines for HIV, have had an allergic reaction to similar medicines in the past, or have osteoporosis. Alcohol does not interfere with the way Neksium 20 Tablet works. However, drinking alcohol makes your stomach produce more acid than normal. This medicine can make you feel dizzy, sleepy, or affect your vision. If this happens, do not drive, cycle, or use machinery or tools until you feel better. It is not usually recommended during pregnancy and breastfeeding.



In Treatment of Gastroesophageal reflux disease (Acid reflux)

GERD is a chronic (long-term) condition that is like having heartburn consistently rather than just occasionally. It happens because a muscle above your stomach relaxes too much and allows stomach contents to come back up into your esophagus and mouth. Neksium 20 Tablet belongs to a group of medicines called proton pump inhibitors. It reduces the amount of acid your stomach makes and relieves the pain associated with heartburn and acid reflux. You should take it exactly as it is prescribed for it to be effective.

Some simple lifestyle changes can help reduce the symptoms of GERD. Think about what foods trigger heartburn and try to avoid them; eat smaller more frequent meals; try to lose weight if you are overweight and try to find ways to relax. Do not eat within 3-4 hours of going to bed.

In Treatment of Peptic ulcer disease

Neksium 20 Tablet belongs to a group of medicines called proton pump inhibitors. It reduces the amount of acid your stomach makes which prevents further damage to the ulcer as it heals naturally. You may be given other medicines along with this medicine depending on what caused the ulcer. You need to keep taking the medicine as it is prescribed for it to be effective, even if the symptoms seem to disappear.

In Treatment of Zollinger-Ellison syndrome

Zollinger-Ellison syndrome is a rare disorder where excessive stomach acid production leads to multiple peptic ulcers. Symptoms include abdominal pain, diarrhea, and heartburn. Neksium 20 Tablet By reducing the production of stomach acid, it helps alleviate symptoms such as abdominal pain, heartburn, and diarrhea. Esomeprazole also aids in the healing of peptic ulcers, which are common in this condition. By controlling the excessive acid secretion associated with Zollinger-Ellison syndrome, esomeprazole helps improve the overall digestive health and prevents complications such as gastrointestinal bleeding.



Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Neksium 20 Tablet is to be taken empty stomach.



Neksium 20 Tablet is a proton pump inhibitor (PPI). It works by reducing the amount of acid in the stomach which helps in relief of acid related indigestion and heartburn.





Caution is advised when consuming alcohol with Neksium 20 Tablet. Please consult your doctor.


Information regarding the use of Neksium 20 Tablet during pregnancy is not available. Please consult your doctor.

Breast feeding

Information regarding the use of Neksium 20 Tablet during breastfeeding is not available. Please consult your doctor.
Caution should be exercised when Neksium 20 Tablet is administered to breastfeeding women.


Neksium 20 Tablet may cause side effects which could affect your ability to drive.
In rare cases, Neksium 20 Tablet may cause dizziness and blurred vision, do not drive or use machines if you experience such symptoms.


Neksium 20 Tablet is safe to use in patients with kidney disease. No dose adjustment of Neksium 20 Tablet is recommended.
However, due to lack of data, exercised should be caution in patients with severe renal insufficiency.


Neksium 20 Tablet should be used with caution in patients with severe liver disease. Dose adjustment of Neksium 20 Tablet may be needed. Please consult your doctor.
However, no dose adjustment is required for patients with mild to moderate liver disease.


Interaction with drugs

  • Diazepam : (SERIOUS)
  • Nitrazepam : (SERIOUS)
  • Clonazepam : (SERIOUS)
  • Clobazam : (SERIOUS)
  • Alprazolam : (SERIOUS)
  • Lorazepam : (SERIOUS)
  • Methotrexate : (MODERATE)
  • Phenytoin : (MODERATE)
  • Clopidogrel : (MINOR)
  • Roxithromycin : (MINOR)




If you miss a dose of Neksium 20 Tablet, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.


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Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Common side effects of Neksium

  • Headache
  • Dryness in mouth
  • Nausea
  • Abdominal pain
  • Constipation
  • Flatulence
  • Diarrhea


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Q. What is the best time to take Neksium 20 Tablet?

Usually, Neksium 20 Tablet is taken once a day, first thing in the morning. If you take Neksium 20 Tablet twice a day, take 1 dose in the morning and 1 dose in the evening. The tablets should be swallowed whole (remember not be chewed or crushed) and taken at least 1 hour before a meal with some water.

Q. Can I take Neksium 20 Tablet with domperidone?

Yes, Neksium 20 Tablet can be safely taken with domperidone as no harmful effects have been reported clinically. A fixed-dose combination of these two medicines is also available. Domperidone works by increasing the gut motility and Neksium 20 Tablet decreases the acid production in the stomach. So, this combination is very effective in the treatment of reflux esophagitis associated with acidity, heartburn, intestinal and stomach ulcers.

Q. Can I take antacids along with Neksium 20 Tablet?

Yes, you can take antacids along with Neksium 20 Tablet. Take it 2 hours before or after you take Neksium 20 Tablet.

Q. Can I take Neksium 20 Tablet for a long term?

Neksium 20 Tablet is usually prescribed for short term use only. However, if need arises, such as for treating peptic ulcer disease and Zollinger Ellison syndrome (ZES), Neksium 20 Tablet may be prescribed for a long term duration as well. Long term use may carry an increased risk for side effects and must be discussed with the doctor. Please use Neksium 20 Tablet as advised by your doctor and under their supervision.

Q. What are the long term side effects of Neksium 20 Tablet?

If Neksium 20 Tablet is used for more than 3 months, certain long term side effects may be seen. The most important of these is low magnesium levels in your blood which may make you feel tired, confused, dizzy, shaky or dizzy. You may also have muscle twitches or irregular heartbeat. If the use is further prolonged for more than a year, you may have an increased risk of bone fractures, stomach infections and vitamin B12 deficiency. Vitamin B12 deficiency can make you anemic, as a result of which you may feel more tired, weak, or pale. Additionally you may have palpitations, shortness of breath, lightheadedness, indigestion, loss of appetite, flatulence (gas) or nerve problems such as numbness, tingling and problem in walking.

Q. Can I stop taking Neksium 20 Tablet if I feel better?

If you have been taking Neksium 20 Tablet for a long time, stopping it abruptly may lead to increased acid production, thereby worsening your symptoms. Therefore, you must discuss any dose changes or if you wish to come off Neksium 20 Tablet.

Q. Can Neksium 20 Tablet cause weight gain?

Weight gain is reported in less than 1% of the patients taking Neksium 20 Tablet but the exact cause is unknown. One possible explanation is higher food intake once the reflux symptoms are relieved. Lifestyle modifications such as proper diet and exercise can help to prevent weight gain.

Q. Is Neksium 20 Tablet safe to use?

Yes, Neksium 20 Tablet is relatively safe to use. Most of the people who take Neksium 20 Tablet do not get a side effect. It is advised to be taken as directed by the doctor for maximum benefit.

Q. Can I take Neksium 20 Tablet with ranitidine?

Yes, Neksium 20 Tablet can be taken with ranitidine. According to research reports, there are no significant interactions seen between Neksium 20 Tablet and ranitidine. However, you must take them together only if prescribed by the doctor.

Q. Can I take alcohol with Neksium 20 Tablet?

No, alcohol intake is not advised with Neksium 20 Tablet. Alcohol itself does not affect the working of Neksium 20 Tablet, but it can increase the acid production. This may further cause worsening of your symptoms


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Pack size  – 1*15

pack form  – tablet



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 Information Leaflet

Always read the patient information leaflet before commencing treatment.

Important: We advise you to always read the patient information leaflet inside the medication box, as the generic medication may not always entirely match the patient information leaflet listed. Please contact us if you have any questions.

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