Generic : Tocilizumab (400mg)

Treatment : Ankylosing spondylitis, Rheumatoid arthritis, Psoriasis, Ulcerative colitis, Crohn’s disease

Pack size  : 20 ml in 1 vial

Manufacturer : Hetero Healthcare Limited

Made In : INDIA

Unit Price



Tocira 400 Infusion is a medicine used to treat various inflammatory conditions of the joints (rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis), skin (psoriasis), and bowel (ulcerative colitis, Crohn’s disease). It reduces swelling in these conditions by blocking TNF alpha.

Tocira 400 Infusion is given by a healthcare professional and should not be self-administered. You should use it regularly and at the same time each day to get the maximum benefit from it. Continue using it as recommended by your doctor and complete the dose even if you feel better.

To make sure the medicine is safe for you, before taking it, let your doctor know if you have any problems with your heart, kidneys, or liver. You should also tell your doctor about all the other medicines you are taking. While on treatment with this medicine, your doctor may monitor your blood counts by taking regular blood tests to make sure the medicine is not affecting your blood counts. It is important for pregnant and breastfeeding women to ask the advice of their doctors before taking this medicine.



In Treatment of Ankylosing spondylitis

Ankylosing spondylitis is a condition that mainly affects the spine. It causes severe pain and stiffness from the neck to the lower back.
Tocira 400 Infusion acts by lowering the activity of chemicals that causes pain and swelling. Tocira 400 Infusion slows down any damage caused by the disease and reduces the possibility of long-term disability.
Tocira 400 Infusion is a slow-acting medicine so you won’t notice an immediate effect but they’re very effective over a period of time. So it is advisable to take it as prescribed by your doctor.

In Treatment of Rheumatoid arthritis

Rheumatoid arthritis or RA is an autoimmune disorder, in which the immune system starts attacking the lining of your joints. This causes pain and swelling in the joints.

Tocira 400 Infusion helps treat rheumatoid arthritis. It makes the immune system function normally and prevents it from attacking the body. This gives relief from the symptoms such as pain, swelling, and stiffness in the joints. This helps in easy movement and makes you do your daily activities more easily.

You may notice some relief of joint swelling, pain, and stiffness within the first 8 weeks of treatment with Tocira 400 Infusion.

In Treatment of Psoriasis

Psoriasis is a condition where the cells in the body grow too quickly and form scales and dry, itchy patches. They can grow anywhere, but most appear on the elbows, knees, scalp, and lower back. Tocira 400 Infusion reduces the scaly, itchy patches which may develop on different parts of the body. It also reduces dryness associated with Psoriasis and improves skin condition. This helps boost your self-confidence and improves quality of your life. It may take several months to become fully effective. Use it exactly and for as long as it is prescribed to get the most benefit.

In Treatment of Ulcerative colitis

Ulcerative colitis is a condition that causes redness and swelling in the large intestine and the rectum (lower part of large intestine). This can cause bleeding, frequent passing of stool and stomach pain. Tocira 400 Infusion reduces the pain and swelling and gives you relief from these symptoms. It reduces the discomfort and helps you live your life normally.
Tocira 400 Infusion if taken as prescribed can prevent the return of ulcerative colitis flare (return or worsening of your symptoms). Drink plenty of fluids while taking it to make sure you stay hydrated.

In Treatment of Crohn’s disease

Crohn’s disease is a condition that causes redness and swelling in any part of the digestive system from mouth to the anus. It can cause severe stomach pain.
Tocira 400 Infusion works by blocking chemicals causing pain and swelling. Thereby giving relief and helping you to live a normal life. This medicine is given as an injection. You should always take it as it has been prescribed for you.



Your doctor or nurse will give you this medicine. Kindly do not self-administer.



Tocira 400 Infusion blocks the action of certain chemical messengers that are responsible for inflammation, swelling and redness associated with certain joint diseases.





Consuming alcohol with Tocira 400 Infusion does not cause any harmful side effects.


Tocira 400 Infusion may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.

Breast feeding

Tocira 400 Infusion is probably safe to use during breastfeeding. Limited human data suggests that the drug does not represent any significant risk to the baby.


Tocira 400 Infusion may decrease alertness, affect your vision or make you feel sleepy and dizzy. Do not drive if these symptoms occur.


Tocira 400 Infusion should be used with caution in patients with kidney disease. Dose adjustment of Tocira 400 Infusion may be needed. Please consult your doctor.
Limited information is available on the use of Tocira 400 Infusion in patients with moderate to severe kidney disease. No dose adjustment is required in patients with mild kidney disease.


Tocira 400 Infusion should be used with caution in patients with liver disease. Dose adjustment of Tocira 400 Infusion may be needed. Please consult your doctor.
Use of Tocira 400 Infusion is not recommended in patients with active liver disease.


Interaction with Drugs




If you miss a dose of Tocira 400 Infusion, please consult your doctor.


Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Common side effects of Tocira

  • Headache
  • High blood pressure
  • Upper respiratory tract infection
  • Injection site reactions (pain, swelling, redness)


Q. Who should be treated with Tocira 400 Infusion?

Tocira 400 Infusion should be given for treating patients suffering from moderate to severe Covid-19 infection who have persistent reduction in their oxygen levels (a condition called hypoxia) that continues to get worse. The hypoxia may continue to get worsened even after 24 to 48 hours of treatment with corticosteroids and supportive care.

Q. Is Tocira 400 Infusion recommended for all Covid-19 patients? If not, why?

No, Tocira 400 Infusion is not recommended for all Covid-19 patients. This is because Tocira 400 Infusion has its own potential health hazards. Tocira 400 Infusion can lead to persistent serious infection and prolonged multiplication and shedding of the virus causing infection, so, it must be given only if the benefits outweigh the risks involved.

Q. What are the side effects of Tocira 400 Infusion?

The potential side effects of Tocira 400 Infusion include anaphylaxis (serious allergic reaction) with infusion, transaminitis (very high levels of liver enzymes due to which they start moving into the bloodstream), leukopenia (a condition where a person has reduced white blood cells and hence increased risk for infections) and neutropenia (a condition where a person has abnormally low number of cells called neutrophils, that fight infections in our body). Some other side effects are risk of serious bacterial infections, viral infections and reactivation of tuberculosis (TB) virus.

Q. Who should not be given Tocira 400 Infusion?

Tocira 400 Infusion should not be given to patients who have or ever had abnormal levels of liver enzymes (transaminitis), platelet counts (<50000), or if they have TB, or any active bacterial or viral infection. The use of Tocira 400 Infusion is contraindicated in pregnancy and breastfeeding mothers too, owing to its risk of developing serious complications.

Q. What to do if there is no improvement seen after giving Tocira 400 Infusion too?

Your doctor will decide the next course of action if there is no improvement seen even after giving Tocira 400 Infusion. Tocira 400 Infusion will prevent inflammation of the lungs but will not cure the damage already done due to the existing disease. Recovery of the lungs takes time to improve. Persistent breathlessness after Tocira 400 Infusion administration requires further evaluation of patients for other lung-related issues (pulmonary intravascular coagulopathy) or heart-related problems (cardiac dysfunctions). Any other bacterial infections that might have occurred should also be treated separately.


Pack size  – 20ml * 1

pack form  -Injection


 Information Leaflet

Always read the patient information leaflet before commencing treatment.

Important: We advise you to always read the patient information leaflet inside the medication box, as the generic medication may not always entirely match the patient information leaflet listed. Please contact us if you have any questions.